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. 2015 Jul 23;5:12411. doi: 10.1038/srep12411

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(a) Heavy chain germline gene segment usage and the CDR sequence logos of scFvs (S316 set) selected for binding to HER2/ECD from the phage-displayed mouse antibody libraries are shown. The phylogenetic tree is color-coded according to the mouse origin; the 6 representative antibodies (M32, M41, M61, M62, M63, M64) are indicated. The black dots next to the tree branches mark the representative antibody variants used in Fig. 5a. The germline sequence segment names and CS types (colored in red) are labeled and the sequence logos for the CDRs are shown next to the phylogenetic tree. The x-axis of the logo plots is marked by the Kabat number of the CDR residues. (b) Light chain germline gene segment usage and the CDR sequence logos of scFvs (S316 set) selected for binding to HER2/ECD from the phage-displayed mouse antibody libraries are shown. Descriptions of this panel are the same as in (a).