Table 2. Cox proportional hazards regression with competing risk of death for renal function recovery within 6 months after acute tubular necrosis.
| Parameter variable | Renal function recoverya within 6 months |
|||||
|---|---|---|---|---|---|---|
| Model 1 adjusted for age and sex | Model 2 adjusted for statistically significant covariates in Table 1 | Model 3 adjusted for age, sex and other variablesb | ||||
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
| Tubular PRX3 high expression | 15.45 (2.18–109.23) | 0.006 | 8.74 (1.22–62.47) | 0.03 | 8.99 (1.13–71.52) | 0.04 |
| Hypertension | 0.40 (0.14–1.12) | 0.08 | ||||
| Diabetes mellitus | 0.42 (0.14–1.24) | 0.12 | ||||
| Tubular atrophy (%) | 0.91 (0.82–1.01) | 0.08 | ||||
| Interstitial fibrosis (%) | 0.96 (0.90–1.02) | 0.15 | ||||
| Severity of AKI (KDIGO 2, 3 vs KDIGO 1) | 2.65 (0.81–8.6) | 0.11 | ||||
| Baseline eGFR (10 ml/min/1.73 m2) | 1.12 (1.00–1.24) | 0.04 | 1.05 (0.93–1.18) | 0.41 | ||
| Urinary protein-to-creatinine ratio (mg/mg) | 0.75 (0.62–0.90) | 0.002 | 0.88 (0.75–1.04) | 0.14 | ||
| Hemoglobin (g/dl) | 1.33 (1.11–1.61) | 0.003 | 1.26 (1.06–1.5) | 0.008 | 1.28 (1.05–1.56) | 0.01 |
| Serum albumin (g/dl) | 0.93 (0.58–1.51) | 0.78 | ||||
| Concomitant use of ACEIs or ARBs | 0.47 (0.13–1.66) | 0.24 | ||||
| Concomitant use of immunosuppressants | 0.64 (0.25–1.63) | 0.35 | ||||
aIncludes complete recoveries and partial recoveries.
bModel 3 included significant covariates in Model 1.
ACEI, Angiotensin-converting enzyme inhibitor; AKI, acute kidney injury; ARB, angiotensin-II receptor blocker; eGFR, estimated glomerular filtration rate; KDIGO, Kidney Disease: Improving Global Outcomes; PRX3, peroxiredoxin 3.