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. 2017 Mar 29;6(3):e14. doi: 10.1038/emi.2016.140

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Sequence alignment of CoV S protein RBD. The RBD of S protein from F46, Human/Civet CoVs and other closely related bat SARS-like CoVs were aligned using ClustalW 2.0. The key amino-acid residues involved in the interaction with human ACE2 are indicated by arrows. Angiotensin-converting enzyme 2, ACE2; coronavirus, CoV; open reading frame, ORF; receptor-binding domain, RBD; severe acute respiratory syndrome, SARS.