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. 2017 Mar 27;8:14764. doi: 10.1038/ncomms14764

Figure 3. Primary and tertiary structural comparison of Zika and dengue virus NS5 RdRp.

Figure 3

(a) Superposition (left) and coloured differences (right) of the NS5 RdRp structures of DENV2 (green) and ZIKV (blue). (b) Superposition (left) and coloured differences (right) of the NS5 RdRp structures of DENV3 (wheat) and ZIKV (blue). In the right panel, mutations are coloured by percentage of difference in a blue–red scale, based on a BLOSUM90 substitution matrix. (c) Alignment of the NS5 RdRp sequences of ZIKV, DENV2 and DENV3, with secondary structure of ZIKV depicted at the top. Red boxes show conserved residues, while blue boxes show conserved substitutions. Helix were named with H, while strands with S.