Table 3. Associations of the CAPN3 and FRMD5 variants and serum lipid phenotypes in the Jing and Han populations.

Allele/Genotype	TC (mmol/L)1	TG (mmol/L)2	HDL-C (mmol/L)	LDL-C (mmol/L)	ApoA1 (g/L)	ApoB (g/L)	ApoA1/ApoB
CAPN3 rs4344713 T > C
Jing
TT	5.29 ± 0.90	1.50 (1.17)	1.81 ± 0.46	2.84 ± 0.43	1.31 ± 0.25	1.07 ± 0.25	1.29 ± 0.38
CT/CC	5.34 ± 0.78	1.59 (1.28)	1.77 ± 0.42	2.95 ± 0.42	1.27 ± 0.23	1.11 ± 0.26	1.21 ± 0.42
F	0.222	−1.517	2.564	5.763	3.021	5.245	6.510
P	0.637	0.129	0.110	0.016	0.082	0.022	0.011
Han
TT	4.98 ± 0.79	1.36 (1.09)	1.86 ± 0.47	2.86 ± 0.43	1.33 ± 0.20	1.04 ± 0.24	1.34 ± 0.38
CT/CC	4.99 ± 0.88	1.50 (1.17)	1.76 ± 0.54	2.90 ± 0.43	1.33 ± 0.19	1.07 ± 0.24	1.29 ± 0.32
F	0.007	−1.918	0.429	0.403	0.030	0.542	0.861
P	0.935	0.055	0.513	0.526	0.862	0.462	0.354
FRMD5 rs524908 A > C
Jing
AA	5.28 ± 0.91	1.50 (1.17)	1.81 ± 0.48	2.82 ± 0.46	1.32 ± 0.26	1.06 ± 0.25	1.31 ± 0.38
AC	5.30 ± 0.87	1.54 (1.24)	1.80 ± 0.44	2.85 ± 0.42	1.28 ± 0.21	1.08 ± 0.25	1.25 ± 0.37
CC	5.36 ± 0.79	1.59 (1.28)	1.77 ± 0.41	2.97 ± 0.41	1.28 ± 0.23	1.13 ± 0.26	1.21 ± 0.43
F	0.371	−1.679	1.180	4.584	3.674	5.847	7.701
P	0.690	0.093	0.307	0.010	0.026	0.003	0.000
Han
AA	4.87 ± 0.80	1.36 (1.07)	1.81 ± 0.51	2.86 ± 0.42	1.33 ± 0.21	1.04 ± 0.23	1.34 ± 0.39
AC	4.98 ± 0.84	1.46 (1.12)	1.75 ± 0.57	2.87 ± 0.43	1.33 ± 0.20	1.05 ± 0.24	1.34 ± 0.36
CC	4.99 ± 0.89	1.49 (1.13)	1.70 ± 0.39	2.89 ± 0.44	1.27 ± 0.18	1.09 ± 0.21	1.21 ± 0.31
F	1.400	−1.525	0.598	0.082	2.282	0.294	2.157
P	0.247	0.127	0.550	0.922	0.102	0.746	0.116

TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B. ¹Mean ± SD determined by the ANCOVA. ²Median (interquartile range) tested by the Wilcoxon-Mann-Whitney test or Kruskal-Wallis test. A P-value less than 0.025 was considered statistically significant after the Bonferroni correction.