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. 2015 Jan 8;5:7608. doi: 10.1038/srep07608

Figure 9. ABC protects from Aβ1–42 accumulation and synaptic loss, and from consequent downstream BDNF deregulation in vivo.

Figure 9

ABC protected from Aβ1–42 endogenous secretion in mice hippocampi (a) (n = 6) preserving synapse integrity assessed by synaptophysin protein quantification (b) (n = 6). (c) BDNF protein level was normalised in mice hippocampi following ABC treatment (n = 6). A higher efficacy was observed for ABC with respect to single drugs. ABC was composed of ACP 0.2 mg Kg−1 and BCL 3 mg Kg−1. Values are mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001 versus Aβ; ANOVA with Dunnett's test. Sc.: scrambled.