Table 2. Immune and neurotrophic factors identified by shot-gun analyses from MSCs and SCI. Sequence coverage are established from shot gun analyses using LTQ-Orbitrap XL mass spectrometer and based on protein identification with a protein threshold of 99% (FDR 0.1%) and peptide threshold of 97% (0.1%) and contained at least 2 identified peptides (see Supplementary data 2).
| ProteinFamily | Protein Name | Accession Number | SequenceCoverage |
|---|---|---|---|
| Chemokines | CCL3 | P50229 | 35% |
| CXCL2 | P303484 | 49% | |
| C1qc | P31722 | 16% | |
| cC1qR | O35796 | 20% | |
| MIF | P30904 | 36% | |
| Immune | ST2(ILRL1) | Q62611 | 24% |
| Regulators | CLEC11a | O88201 | 20% |
| Gal 1 | P11762 | 64% | |
| Gal 3 | P08699 | 9% | |
| Arginase 1 | P07824 | 9% | |
| CD | CD9 | P40241 | 15% |
| CD14 | Q63691 | 17% | |
| CD59 | P27274 | 30% | |
| GrowthFactors | CTGF | Q9R1E9 | 56% |
| BDNF | P23363 | 12% | |
| TGFb1 | P17246 | 16% | |
| TGF b2 | Q07257-2 | 18% | |
| TGF b3 | Q07258 | 12% | |
| PGF | Q63434 | 22% | |
| PDGF | Q5RJP7 | 19% | |
| IGFbp7 | F1M9B2 | 54% | |
| BMP1 | F1M798 | 4% | |
| Epdr1 | Q5XII0 | 19% | |
| C1q/TNF5 | Q5FVH0 | 28% | |
| Neurotrophic Factors | Neurotrimin | Q62718 | 16% |
| GAP43 | P07936 | 63% | |
| Calumenin | O35783 | 36% | |
| Neural Migration Factor | Neuroplastin | P97546 | 10% |
| Neuropilin 2 | 035276 | 3.7% | |
| Neuromodulin | P07936 | 63% | |
| NOV | Q9QZQ5 | 30% | |
| Metalloproteinase | TIMP-1 | P30120 | 71% |
| TIMP-2 | P30121 | 54% | |
| Osteogenic Factors | Osteoglycin | D3VZB7 | 13% |
| Osteopontin | PO8721 | 21% | |
| Périostin | D3ZAF5 | 66% | |
| Differentiating factors | SPARC | P16975 | 60% |
| FAM3C | Q10F4 | 9% | |
| Cornifin | Q63532 | 11% |