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. 2017 Mar 21;18(12):3005–3017. doi: 10.1016/j.celrep.2017.02.079

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© 2017 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Transcription Factor Dependency of Cardiac cDC Subsets

(A) Representative histogram of IRF4 and IRF8 expression of steady-state WT heart cDC1s, cDC2s, and moDCs.

(B) MFI of IRF4 and IRF8 expression on naive WT heart DC subsets shown in (A).

(C and D) MHCII⁺CD11c⁺CD64⁻ cDCs are divided into CD24⁺CD172α⁻ cDC1s, CD24⁺CD172α⁺ cDC2s, and CD24⁻CD172α⁺ cDC2s in Irf4^fl/fl and Irf4^fl/fl.Cd11cCre steady-state heart (C) and mediastinal LN (D).

(E) Percentage of living cells of cDCs in Irf4^fl/fl and Irf4^fl/fl.Cd11cCre naive heart and mLN.

(F and G) MHCII⁺CD11c⁺CD64⁻ cDCs are divided into CD24⁺CD172α⁻ cDC1s, CD24⁺CD172α⁺ cDC2s, and CD24⁻CD172α⁺ cDC2s in Irf8^fl/fl and Irf8^fl/fl.Cd11cCre steady-state heart (F) and mLN (G).

(H) Percentage of living cells of cDCs in Irf8^fl/fl and Irf8^fl/fl.Cd11cCre steady-state heart and mLN. All data in Figure 2 represent at least two independent experiments, and all bar graphs show data as mean ± SEM (^∗p ≤ 0.05).