Table 5. Gene Ontology (GO) function profile from P. brasiliensis, C. neoformans, C. albicans, and S. cerevisiae EVs. * p-value < 0.05.

Sp	GO – Cellular Process	EVs/genome ratio*
C. neoformans	Growth	3.61
	Cytoskeleton organization	3.06
	Signal transduction	2.37
	Homeostatic process	1.97
	Vesicle-mediated transport	1.94
	Cell cycle	1.9
	Protein targeting	1.69
	Reproduction	1.57
	Cellular protein modification	1.35
C. albicans	Vesicle-mediated transport	2.43
	Catabolic process	2.1
	Transport	2.09
	Cellular protein modification	1.7
	Cellular component assembly	1.63
	Cell cycle	1.41
S. cerevisiae	Cellular protein modification	2.18
	Small molecule metabolic process	1.82
	Ribosome biogenesis	1.73
	Transport	1.61
	Response to stress	1.54
	Cellular nitrogen compound metabolic process	1.41