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. 2017 Mar 28;8:14782. doi: 10.1038/ncomms14782

Figure 7. BLA-2-AG signalling is required for resilience to repeated traumatic stress.

Figure 7

(a) Effect of AAV-GFP vs. AAV-GFP-CRE BLA-injection on home cage NIH training (blue lines) and novel cage latency (top) and consumption (bottom) with no stress (NC), 24 h after 1 day of stress (NC-1FS), and 24 h after a 5th day of stress (NC-5FS). (b) AAV-GFP latency (top) and consumption (bottom) from a split into resilient (black) and susceptible (red) groups. (c) AAV-GFP-CRE latency (top) and consumption (bottom) from a split into resilient (black) and susceptible (red) groups. (d) 5-day stress susceptibility ratios for BLA AAV-GFP and AAV-GFP-CRE injected groups. (e) Paired individual baseline and post-stress latencies in AAV-GFP and AAV-GFP-CRE BLA-injected groups. (f) Direct comparison of stress-induced changes in latency in resilient and susceptible AAV-GFP vs. AAV-GFP-CRE BLA-injected mice. Data combined from 2 independent cohorts. Blue arrows in a–c indicate stress exposure, which occurred once per day for 5 consecutive days. F and P values for two-way ANOVA shown above individual (a–c,f). P values for pairwise comparisons derived from Holm-Sidak multiple comparisons test after ANOVA, paired two-tailed t-test (e), and chi-squared test reported (d) in each panel. Data are presented as mean±s.e.m.