Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Mar 28;8:14782. doi: 10.1038/ncomms14782

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(a) Effect of JZL-184 incubation on the inter-event interval (IEI; left), frequency (left inset) and amplitude (right) of spontaneous excitatory postsynaptic currents (sEPSCs) onto BLA pyramidal cells in control non-stressed mice, and (b) 24 h after foot-shock stress exposure. (c) Direct comparison of stress effect and JZL-184 effect from a and b. (d) Direct comparison of resilient (left; black) and susceptible (right; red) BLA sEPSC frequency (top) and amplitude (bottom) with vehicle (VEH) and either JZL-184 (blue hash) or Rimonabant (RIM; orange hash) incubation. (e) Direct comparison of the dynamic range of eCB signalling (defined as the difference in sEPSC frequency (top) and amplitude (bottom) between JZL-184 and Rimonabant conditions shown in d with representative traces in f. Number of cells is shown for each group. Number of (cells; animals) are reported in a and b. Number of cells reported in d. F and P values for one-way (d) or two-way (c,e) ANOVA shown above individual panels. P value for pairwise comparisons derived from Holm-Sidak multiple comparison test after ANOVA (c–e) or unpaired t-test (a,b) shown in individual panels. Data are presented as mean±s.e.m.