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. 2017 Mar 21;2017:6510198. doi: 10.1155/2017/6510198

Figure 6.

Figure 6

Ginsenoside Rg1 inhibited TGF-β1/Smad pathway in pulmonary fibroblasts stimulated by cigarette smoke extract (CSE) and mimicked the effect of SB525334 on CSE-induced pulmonary fibroblasts. (a) The concentration of TGF-β1 in serum was determined by ELISA. (b) The concentration of TGF-β1 in the cell supernatant was determined by ELISA. (c) Western blot and quantitative analysis of TGFβRI protein expression. (d) Western blot and quantitative analysis of p-Smad2 and p-Smad3 protein expression. (e) Western blot and quantitative analysis of α-SMA, collagen I, MMP-9, and TIMP-1 protein expression. Data (a, b, c, and e) are shown as the mean ± SD. ∗∗p < 0.01 versus the Sham group; ##p < 0.01 versus the CSE group; Δp < 0.05 and ΔΔp < 0.01 versus the CSE + Rg1 + SB525334 group. Data (d) are expressed as the mean ± SD. ∗∗p < 0.01 versus the corresponding ginsenoside Rg1(−) group.