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. 2017 Mar 30;8:14860. doi: 10.1038/ncomms14860

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Copyright © 2017, The Author(s)

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(a) Structures of RAPTA-T and AUF. (b) Effect of combinations of RAPTA-T with AUF on cytotoxicity towards A2780 tumour cells (mean±s.d., n=3). (c) CI as a function of drug concentration (additive effect, CI=0.9–1.1; slight synergism, CI=0.7–0.9; synergism, CI=0.3–0.7; strong synergism, CI=0.1–0.3; mean±s.d., n=3). (d) Drug uptake into nucleosomes measured by ICP-MS after treatment with either RAPTA-T or AUF alone or the combination of the two (mean±s.d., n=3).