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. 2017 Mar 30;8:14860. doi: 10.1038/ncomms14860

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(a) View of one face of the nucleosome core, with the histone octamer rendered with an electrostatic potential surface (red, negative; blue, positive). RAPTA-T binds within the extensive electronegative region on the H2A–H2B dimer, known as the acidic patch. (b) Structure of RAPTA-T-histone adducts. Ruthenium ion-coordinating side chains are labelled. H2A and H2B histone proteins are shown, respectively, with yellow and salmon coloured carbon backbones. An arrow indicates the van der Waals contact between the carrier ligands of the RU1 and RU2 adducts.