Table 3. Adjusted HRa and 95% CI for associations between body weight change, and oesophageal and gastric cardia adenocarcinoma incidence, NIH-AARP Diet and Health Study, and PLCO Cancer Screening Trial.
|
Oesophageal adenocarcinoma |
Gastric cardia adenocarcinoma |
||||
|---|---|---|---|---|---|
| Weight change, kg | Non-cases (n) | Cases (n) | HR (95% CI) | Cases (n) | HR (95% CI) |
|
Age 20–50 | |||||
| ⩽−2 | 22 786 | 16 | 0.65 (0.38, 1.11) | 15 | 0.95 (0.54, 1.69) |
| >−2 to <5 | 75 150 | 86 | Referent | 53 | Referent |
| ⩾5 to <15 | 160 521 | 235 | 1.06 (0.83, 1.36) | 158 | 1.17 (0.86, 1.61) |
| ⩾15 | 133 708 | 267 | 1.26 (0.98, 1.62) | 159 | 1.23 (0.90, 1.70) |
| ⩾20b | 80 714 | 171 | 1.35 (1.03, 1.76) | 105 | 1.36 (0.97, 1.91) |
| Continuous, kg | 1.01 (1.00, 1.02) | 1.01 (1.00, 1.02) | |||
| Pfor trend | 0.006 | 0.05 | |||
|
Age 20 to baseline | |||||
| ⩽−2 | 21 169 | 20 | 1.11 (0.65, 1.89) | 15 | 1.07 (0.58, 1.97) |
| >−2 to <5 | 51 448 | 43 | Referent | 33 | Referent |
| ⩾5 to <15 | 127 569 | 170 | 1.43 (1.02, 2.00) | 136 | 1.49 (1.02, 2.17) |
| ⩾15 | 191 979 | 371 | 1.84 (1.34, 2.54) | 201 | 1.28 (0.88, 1.85) |
| ⩾20b | 133 786 | 277 | 1.97 (1.43, 2.73) | 155 | 1.40 (0.96, 2.05) |
| Continuous, kg | 1.02 (1.01, 1.02) | 1.01 (1.01, 1.02) | |||
| Pfor trend | <0.0001 | 0.0004 | |||
|
Age 50 to baseline | |||||
| ⩽−2 | 61 256 | 80 | 0.79 (0.61, 1.01) | 52 | 0.82 (0.60, 1.11) |
| >−2 to <5 | 201 027 | 287 | Referent | 185 | Referent |
| ⩾5 to <15 | 101 680 | 176 | 1.16 (0.96, 1.40) | 103 | 1.05 (0.82, 1.34) |
| ⩾15 | 28 202 | 61 | 1.57 (1.19, 2.08) | 45 | 1.75 (1.25, 2.43) |
| ⩾20b | 13 740 | 26 | 1.45 (0.97, 2.18) | 20 | 1.66 (1.04, 2.65) |
| Continuous, kg | 1.02 (1.01, 1.03) | 1.02 (1.01, 1.03) | |||
| Pfor trend | <0.0001 | 0.002 | |||
|
Adjusted for average weight (kg) | |||||
|
Age 20–50 | |||||
| ⩽−2 | 22 786 | 16 | 0.56 (0.33, 0.95) | 15 | 0.84 (0.47, 1.50) |
| >−2 to <5 | 75 150 | 86 | Referent | 53 | Referent |
| ⩾5 to <15 | 160 521 | 235 | 1.07 (0.83, 1.37) | 158 | 1.17 (0.86, 1.60) |
| ⩾15 | 133 708 | 267 | 1.16 (0.90, 1.49) | 159 | 1.14 (0.83, 1.57) |
| ⩾20b | 80 714 | 171 | 1.19 (0.91, 1.55) | 105 | 1.22 (0.86, 1.72) |
| Continuous, kg | 1.01 (1.00, 1.01) | 1.01 (1.00, 1.02) | |||
| Pfor trend | 0.1 | 0.2 | |||
|
Age 20 to baseline | |||||
| ⩽−2 | 21 169 | 20 | 0.96 (0.56, 1.64) | 15 | 0.93 (0.50, 1.72) |
| >−2 to <5 | 51 448 | 43 | Referent | 33 | Referent |
| ⩾5 to <15 | 127 569 | 170 | 1.42 (1.02, 1.99) | 136 | 1.48 (1.01, 2.16) |
| ⩾15 | 191 979 | 371 | 1.63 (1.18, 2.24) | 201 | 1.12 (0.77, 1.63) |
| ⩾20b | 133 786 | 277 | 1.68 (1.21, 2.33) | 155 | 1.19 (0.81, 1.76) |
| Continuous, kg | 1.01 (1.00, 1.01) | 1.01 (1.00, 1.02) | |||
| Pfor trend | 0.007 | 0.05 | |||
|
Age 50 to baseline | |||||
| ⩽−2 | 61 256 | 80 | 0.73 (0.57, 0.94) | 52 | 0.77 (0.56, 1.05) |
| >−2 to <5 | 201 027 | 287 | Referent | 185 | Referent |
| ⩾5 to <15 | 101 680 | 176 | 1.04 (0.86, 1.26) | 103 | 0.96 (0.75, 1.23) |
| ⩾15 | 28 202 | 61 | 1.15 (0.86, 1.55) | 45 | 1.36 (0.96, 1.94) |
| ⩾20b | 13 740 | 26 | 0.98 (0.64, 1.49) | 20 | 1.22 (0.75, 1.98) |
| Continuous, kg | 1.01 (1.00, 1.02) | 1.01 (1.00, 1.02) | |||
| Pfor trend | 0.005 | 0.05 | |||
Abbreviations: CI=confidence interval; HR=hazard ratio; PLCO=Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
a
Adjusted for sex, race (non-Hispanic white, non-Hispanic black, other), smoking (never/current/former, and categorised cigarettes per day (0, 1–10, 11–20, 21–30, 31–40, 41–60, 61+)), education (high school or less, technical school or some college, college graduate, postgraduate), study, and height (m).
b
Estimated from a model where this was considered as a distinct category.