Skip to main content
. 2017 Feb 21;116(7):903–911. doi: 10.1038/bjc.2017.32

Figure 3.

Figure 3

PTBP3 knockdown switched the splicing pattern of Bcl-x via modulating PTB expression. Inhibition of PTBP3 (A) in gastric cancer cells promoted the generation of Bcl-xS (B) and upregulated the expression of PTB (C, D) (*P<0.05, **P<0.01, ***P<0.001, Student's t test). (E) PTB knockdown reversed the increase of Bcl-xS/Bcl-xL ratio resulting from PTBP3-silencing. * indicates the difference between the NC group and each of the rest groups; # indicates the difference between the PTBP3 KD and the PTB/PTBP3 KD group (*P<0.05, **P<0.01, ***P<0.001, ##P<0.01, Student's t test).