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Cdk5 inhibition reduces cancer cell motility.(A) FCS-induced migration of non-targeting (nt) or Cdk5 shRNA-transduced T24 cells is shown (mean±s.e.m., *P<0.001, n=3). (B) FCS-induced invasion of T24 cells transduced with non-targeting (nt) or Cdk5 shRNA is shown (mean±s.e.m., *P<0.001, n=3). (C) FCS-induced migration of T24 cells with/without treatment with roscovitine is shown (mean±s.e.m., *P<0.001, n=3).
