Skip to main content
. 2017 Apr 4;7:45827. doi: 10.1038/srep45827

Figure 4. AGEs inhibitor amino guanidine and ER chaperone 4-PBA prevent endothelial dysfunctions in STZ-injected rats.

Figure 4

SD rats were administrated with amino guanidine (100 mg/kg per day) or 4-PBA (1 g/kg/day) for 2 weeks prior to the induction of hyperglycemia for the following 4 weeks. Aortas from rats were cut into rings and were mounted in organ chamber to detect vessel bioactivity. (A) Endothelium-dependent relaxation of the aortic rings in response to Ach. (B) Endothelium-independent relaxation of the aortic rings in response to SNP. Each data point represents relaxation expressed as a percentage of the value obtained for PE-preconstricted aorta. Two aortic rings were isolated from each rat. (C) Serum levels of glycated PON1 in rats. (D) Serum PON1 activity in rats. 10–15 rats per group. *P < 0.05 vs. Control or Vehicle group. #P < 0.05 vs. Diabetes.