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. 2017 Apr 4;7:45819. doi: 10.1038/srep45819

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(A) Relative mRNA expression (fold change) of AVP, CRH, NUCB2, and Oxt in PVN after ICV injection of saline (white bars) or FGF21 (50 ng/2 μl) (black bars) at 18:30. (B) Double immunofluorescence staining of c-Fos and NUCB2/Nesf-1 in PVN after ICV injection of saline or FGF21. (C,D) Percentage of c-Fos-IR neurons in NUCB2/Nesf-1-IR neurons (C), and percentage of NUCB2/Nesf-1-IR neurons in c-Fos-IR neurons (D) at 2 h after injection of saline (white bars) or FGF21 (black bars). White arrows in B indicate the neurons IR to both NUCB2/Nesf-1-and c-Fos. Data are presented as mean ± SEM. **P < 0.01, *P < 0.05 by Student’s t test. n = 4 animals per group.