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. 2017 Apr 4;7:45819. doi: 10.1038/srep45819

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(A) Cumulative food intake (g/BW) after ICV injection of FGF21 (50 pmol; black bars) or saline (white bars) at 09:00. (B) Plasma FGF21 concentration (pg/ml) in ad libitum mice showing the elevated levels during light phase and lowered levels during dark phase. **P < 0.01, *P < 0.05. n = 6 in A and 7 in (B).