Table 8. Genotypic and allelic frequencies of Fas gene -1377 among case patients and control subjects and the association of this SNP with ESCC risk.
| Cases (%) n = 248 | Controls (%) n = 297 | χ2 | P | Crude OR (95%CI) | P | Adjusted OR# (95% CI) | P | |
|---|---|---|---|---|---|---|---|---|
| Genotypes | ||||||||
| GG | 126(50.8) | 120(40.4) | 1 | 1 | ||||
| GA | 97(39.1) | 135(45.5) | 6.330 | 0.042* | 0.684(0.477–0.982) | 0.040* | 0.694(0.470–1.026) | 0.067 |
| AA | 25(10.1) | 42(14.1) | 0.567(0.326–0.987) | 0.045* | 0.511(0.283–0.921) | 0.026* | ||
| Alleles | ||||||||
| G allele | 349(70.4) | 375(63.1) | 6.338 | 0.012* | 1 | 1 | ||
| A allele | 147(29.6) | 219(36.9) | 0.849(0.748–0.965) | 0.012* | 0.834(0.727–0.956) | 0.000** |
*P < 0.05.
**P < 0.01
#. Adjusting for age and gender.