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. 2017 Apr 4;16:41. doi: 10.1186/s12933-017-0524-8

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Cox regression analysis of amputations and long-term mortality related to Rutherford grade and diabetes status. a – d show Cox regression analyses for the end-points amputation and mortality during the 4-year follow-up period within Rutherford grade 5 and Rutherford grade 6. Amputation rate is significantly higher in patients with diabetes (DM; continuous line) compared to non-DM patients (dashed line) in Rutherford grade 5 (a) and Rutherford grade 6 (b). Mortality does not significantly differ between DM and non-DM patients in Rutherford grade 5 (c) and is slightly lower in DM compared to non-DM patients in Rutherford grade 6 (d). p values <0.05 are regarded significant