Table 3.

Cox regression analysis on long-term outcome (mortality and amputation)

	Rutherford grade 5				Rutherford grade 6
	Mortality		Amputation		Mortality		Amputation
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Age	1.05 (1.04–1.05)	<0.001	0.99 (0.99–1.00)	0.010	1.05 (1.05–1.06)	<0.001	1.00 (1.00–1.00)	0.951
Male gender	1.13 (1.04–1.23)	0.003	1.48 (1.34–1.63)	<0.001	1.14 (1.07–1.22)	<0.001	1.27 (1.20–1.35)	<0.001
Hypertension	0.80 (0.74–0.86)	<0.001	0.91 (0.82–1.01)	0.066	0.82 (0.77–0.88)	<0.001	0.93 (0.87–0.99)	0.017
Obesity	0.68 (0.57–0.82)	<0.001	0.79 (0.66–0.94)	0.007	0.81 (0.70–0.93)	0.002	0.96 (0.87–1.07)	0.502
Dyslipidemia	0.75 (0.68–0.82)	<0.001	0.96 (0.86–1.07)	0.442	0.76 (0.70–0.83)	<0.001	0.85 (0.79–0.92)	<0.001
Smoking	0.99 (0.81–1.20)	0.896	0.91 (0.75–1.11)	0.372	0.98 (0.84–1.14)	0.804	0.81 (0.72–0.92)	0.001
Diabetes	0.95 (0.88–1.03)	0.222	1.51 (1.38–1.67)	<0.001	0.92 (0.86–0.98)	0.009	1.33 (1.25–1.41)	<0.001
CAD	1.20 (1.10–1.31)	<0.001	1.04 (0.93–1.16)	0.479	1.25 (1.17–1.34)	<0.001	0.98 (0.91–1.05)	0.514
CHF	1.63 (1.49–1.79)	<0.001	0.94 (0.82–1.08)	0.410	1.50 (1.39–1.61)	<0.001	1.10 (1.02–1.19)	0.012
CKD	1.55 (1.43–1.68)	<0.001	1.33 (1.20–1.47)	<0.001	1.38 (1.30–1.47)	<0.001	0.98 (0.92–1.05)	0.572
Malignancies	1.73 (1.38–2.16)	<0.001	0.97 (0.68–1.37)	0.855	1.93 (1.66–2.24)	<0.001	0.86 (0.72–1.03)	0.106

Cox regression analysis for the end-points mortality and amputation during the 4-year follow-up period in patients at Rutherford grade 5 and Rutherford grade 6. In the proportional hazards model, effect of included variables are presented as Hazard Ratio and corresponding confidence intervals, p values <0.05 are considered significant

Italic values are statistically significant

HR Hazard Ratio; CI confidence interval; CAD coronary artery disease; CHF chronic heart failure; CKD chronic kidney disease