Table 1.

CDD cohort: clinical characteristics and the modalities by which each proband was studied

Subject	Sex	Age at onset (months)	Anxiety prodrome	Multiple regressions	Length of regression (months)a	Level of ID	IQ	Cognitive/developmental testb	Language loss	Social or adaptive loss	Incontinence	Play loss	Motor skills loss	Seizures	10 relative with ASD	Genetics	fMRI	ET	Age at fMRI, ET (months)
CDD03-03	M	30	No	No	5	Profound	18	Mullen	Yes	Yes	Yes	Yes	Yes	No	No	Yes	No	No	n/a
CDD05-03	M	37	Yes	No	9	Severe	16	Mullen	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	176
CDD07-03	M	45	Yes	No	4	Profound	9	Mullen	Yes	Yes	Yes	Yes	Yes	No	No	Yes	No	No	n/a
CDD08-03	M	80	Yes	Yes	3	Moderate	46	DAS	Yes	Yes	No	Yes	Yes	No	No	Yes	Yes	Yes	139, 154
CDD09-03	M	44	No	No	6	Mild	64	DAS	Yes	Yes	No	Yes	No	No	No	Yes	Yes	No	52
CDD10-03	M	38	Yes	No	3	Profound	19	Mullen	Yes	Yes	Yes	Yes	Yes	No	No	Yes	No	Yes	122
CDD11-03	M	40	Yes	No	4	Profound	8	Mullen	Yes	Yes	No	Yes	Yes	No	No	Yes	Yes	No	206
CDD12-03	F	36	Yes	No	3	Severe	33	Mullen	Yes	Yes	Yes	Yes	Yes	No	No	Yes	No	Yes	87
CDD13-03	F	31	No	No	80	Profound	18	Mullen	Yes	Yes	Yes	Yes	Yes	No	MZ twin (CDD)c	Yes	Yes	Yes	92
CDD13-04	F	28	No	Yes	4	Profound	16	Mullen	Yes	Yes	Yes	Yes	Yes	No	MZ twin (CDD)c	Yes	Yes	No	92
CDD15-03	M	84	Yes	Yes	2	Severe	n/a	n/a	Yes	Yes	Yes	Yes	No	No	No	Yes	No	No	n/a
CDD16-03	M	53	Yes	Yes	6	Moderate	n/a	n/a	Yes	Yes	Yes	Yes	No	No	Brother (ASD)	Yes	No	No	n/a
CDD17-03	M	68	Yes	No	3	Moderate	44	DAS	Yes	Yes	No	Yes	No	No	Father (autistic features)	Yes	No	No	n/a
CDD19-03	M	31	No	No	24	Severe	26	Mullen	Yes	Yes	No	Yes	No	No	Brother (autistic features)	No	Yes	No	60
CDD20-03	M	51	Yes	Yes	9	Mild	74	DAS	Yes	Yes	Yes	Yes	No	No	MZ twin (ASD)	Yes	No	No	n/a
CDD21-03	F	30	Yes	No	5	Severe	30	Mullen	Yes	Yes	No	Yes	Yes	No	No	Yes	No	No	n/a
CDD22-03	M	48	Yes	No	4	Severe	30	Leiter	Yes	Yes	Yes	Yes	Yes	No	No	Yes	No	No	n/a

Abbreviations: ASD autism spectrum disorder, CDD childhood disintegrative disorder, DAS Differential Ability Scales, ET eye tracking, F female, fMRI functional magnetic resonance imaging, ID intellectual disability, IQ intelligence quotient, M male, MZ monozygotic

^aIf multiple regressions occurred, the number indicates the length of the first period of regression

^bFor subjects who received the Mullen Scales, their full-scale IQ is based on a ratio IQ

^cSubjects CDD13-03 and 13-04 are monozygotic twin girls with CDD who are counted as one proband for the genetics studies