Table 3.

List of the 14 CpG methylation signatures for oligodendroglioma (ODG) versus diffuse astrocytoma (DA) in the training set and validation set (GSE58218)

			Training set (TCGA cohort)					Validation set (GSE58218 cohort)
No.	CpG ID	Gene name	Average β in ODG	Average β in DA	∆β = (avg β in ODG−avg β in DA)	p value	FDR	Average β in ODG	Average β in DA	∆β = (avg β in ODG−avg β in DA)	p value	FDR
1	cg00873351	CD300LB	0.755	0.227	0.528	1.67E−32	3.9E−32	0.576	0.225	0.351	1.92E−22	2.99E−22
2	cg03492827	NA	0.647	0.192	0.455	8.18E−34	5.73E−33	0.701	0.286	0.415	3.01E−26	2.11E−25
3	cg04437966	FLJ37543	0.500	0.088	0.412	3.99E−33	1.39E−32	0.459	0.102	0.357	2.33E−25	8.16E−25
4	cg07250222	FGFR2	0.753	0.186	0.567	8.68E−30	8.68E−30	0.795	0.301	0.494	5.03E−21	7.04E−21
5	cg07847030	TCF7L1	0.730	0.163	0.567	6.78E−31	1.06E−30	0.798	0.368	0.429	2.62E−19	2.62E−19
6	cg07893801	PLCG1	0.807	0.312	0.495	1.28E−32	3.59E−32	0.737	0.378	0.359	1.61E−20	2.04E−20
7	cg08935418	PTPRN2	0.735	0.231	0.505	6.25E−30	6.73E−30	0.771	0.313	0.458	4.01E−23	7.53E−23
8	cg09772154	FGFR2	0.733	0.194	0.540	5.94E−30	6.73E−30	0.779	0.308	0.472	6.35E−20	6.84E−20
9	cg10363569	PRKAG2	0.675	0.162	0.513	5.1E−30	6.5E−30	0.574	0.196	0.377	5.22E−20	6.09E−20
10	cg12210255	NA	0.662	0.139	0.523	2.53E−33	1.18E−32	0.699	0.237	0.462	1.8E−24	5.05E−24
11	cg13412754	MAPKAP1	0.782	0.311	0.471	4.67E−32	9.34E−32	0.736	0.340	0.396	1.74E−25	8.1E−25
12	cg13598010	NA	0.778	0.175	0.603	1.89E−34	2.65E−33	0.790	0.254	0.536	5.09E−27	7.13E−26
13	cg19093820	GPR156	0.210	0.716	−0.506	3.56E−31	6.23E−31	0.211	0.655	−0.444	4.3E−23	7.53E−23
14	cg23759393	PTPRN2	0.722	0.203	0.518	1.08E−30	1.51E−30	0.790	0.300	0.490	8.76E−24	2.04E−23

NA not associated with any gene