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. 2017 Apr 4;7:45788. doi: 10.1038/srep45788

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Percent age change from baseline in LDL-C at Week 24: Subgroup analysis by (a) atorvastatin dose, (b) rosuvastatin dose, and (c) simvastatin dose (ITT analysis). For each statin type, alirocumab data were analyzed in 3 pools according to alirocumab dose and control. In panel c, simvastatin data for the ALI 75/150 mg Q2W versus ezetimibe study pool are for the COMBO II trial only (simvastatin not used in the OPTIONS studies). ATV, atorvastatin; CI, confidence interval; ITT, intent-to-treat; LS, least squares; RSV, rosuvastatin; SE, standard error; SMV, simvastatin.