Figure 6. Sesamol suppressed tumor growth in nude mice.

To generate xenograft tumor model, the nude mice (Balb/c nu/nu) were injected subcutaneously with 1 × 10⁷/mL HepG2 cells, and then treated with sesamol (100 mg/kg or 200 mg/kg) or saline. (A) The body weight changes; (B) Representative pictures of tumors in each group, and the xenograft tumors volume curve of each group. (C) The protein expressions of Bcl-2, Bax, and their ratio after sesamol treatment in tumor tissue. (D) The expression of Ki67, cleaved-caspase 3, and LC3 was analyzed using IHC. Data presented as mean ± SEM, n = 5 mice per group, ^#p < 0.05, ^##p < 0.01, low dose sesamol treatment group versus control group, *p < 0.05, **p < 0.01 high dose sesamol treatment group versus control group.