Table 2. Metabolites found by ¹H-NMR to have significantly changed in septic neonates at the onset of the disease (D0).

metabolites	ppm	D0 possible		D0 confirmed
		p value	log2fold change	p value	log2fold change
Maltose	5.42	p < 0.05	0.83	p < 0.05	1.48
Glucose	3.28	p < 0.05	1.46	p < 0.05	2.21
Biotin	2.78	p < 0.05	1.16	p < 10−2	2.28
Methylamine	2.60	p < 0.05	0.89	p < 10−2	1.77
Unknown	2.78	p < 0.05	0.78	p < 10−2	1.76
Inosine	8.35	p < 10−2	0.78	p < 0.05	1.27
Methylguanidine	2.83	p < 0.05	0.70	p < 0.05	1.11
Creatine	3.00	p < 0.05	1.95	p < 0.05	3.26
Myo-inositol	3.55	p = 0.05	0.62	p < 0.05	2.05
Quinolinic acid	8.03	p = 0.05	0.87	p < 0.05	1.40

On D3 and D10 they were all found with no significant statistical alteration between the groups. ^#Fold change was calculated based on the mean of each group (septic, control) by using the logarithm of the ratio septic/control for every significant metabolite at each time point.