Table 3. Metabolites found by LC-MS/MS to have significantly changed in septic neonates at the onset of the disease (D0) and their evolution in D3.
| Metabolites | D0 |
D3 |
||||||
|---|---|---|---|---|---|---|---|---|
| Confirmed |
Possible |
Confirmed |
Possible |
|||||
| p value | log2fold change | p value | log2fold change | p value | log2fold change | p value | log2fold change | |
| Valine | <10−3 | 4.01 | <10−2 | 1.35 | >0.05 | <10−2 | 4.71 | |
| Phenylalanine | <10−2 | 2.91 | <10−2 | 3.30 | >0.05 | <0.05 | 5.65 | |
| *Taurine | <0.05 | 1.27 | <10−2 | 3.55 | <10−2 | 2.75 | >0.05 | |
| g-aminobutyric acid | =0.05 | 1.09 | <10−2 | 4.61 | >0.05 | >0.05 | ||
| Isoleucine | <10−2 | 2.74 | <10−2 | 2.59 | <10−2 | 7.06 | <10−2 | 4.44 |
| Glutamic acid | =0.05 | 1.92 | <10−2 | 2.66 | >0.05 | >0.05 | ||
| Hypotaurine | =0.05 | 2.59 | <0.05 | 2.53 | >0.05 | >0.05 | ||
| Trimethylamine-N-oxide | <0.05 | −1.98 | <0.05 | −3.46 | <0.05 | −3.06 | <0.05 | −3.03 |
| *Pyruvic acid | =0.05 | 1.98 | =10−3 | 1.94 | ||||
| Fumaric acid | <10−2 | −2.09 | =0.05 | −1.10 | <10−3 | −3.41 | >0.05 | |
| Lactic acid | <0.05 | 2.56 | <10−2 | 3.37 | >0.05 | <0.05 | 5.04 | |
| Hippuric acid | =0.05 | −2.14 | <0.05 | −1.46 | >0.05 | >0.05 | ||
| *D- Glucose | <10−2 | 1.06 | <0.05 | 3.58 | >0.05 | >0.05 | ||
| Nicotinamide | <10−2 | −3.38 | <10−2 | −2.75 | <10−2 | −2.47 | <0.05 | −2.67 |
| Riboflavine | =0.05 | −0.79 | <10−2 | −1.67 | <10−2 | −5.57 | >0.05 | |
| Thiamine | <0.05 | −1.61 | =0.05 | −0.72 | <0.05 | −1.28 | >0.05 | |
| *Inosine | <10−2 | 1.34 | <10−2 | 2.74 | >0.05 | >0.05 | ||
On D10 they were all found with no significant statistical alteration between the groups.
*Parallel significant change of the metabolite on 1H-NMR data.
Log2fold change was calculated based on the mean of each group (control, septic) by using the logarithm (base 2) of the ratio septic/control for every significant metabolite at each time point.