Table 1. Major histopathological findings.
Organ: finding | Treatment duration | Score | Control | Rotenone |
---|---|---|---|---|
Liver: cytoplasmic change/atrophy | 1 day | incidence | 0 | 5 |
severity | — | 3.2 | ||
3 days | incidence | 0 | 5 | |
severity | — | 2.8 | ||
2 weeks | incidence | 0 | 5 | |
severity | — | 3.6 | ||
Bone marrow femur: hyperemia/sinus dilation | 1 day | incidence | 0 | 2 |
severity | — | 0.8 | ||
3 days | incidence | 0 | 5 | |
severity | — | 2.0 | ||
2 weeks | incidence | 0 | 5 | |
severity | — | 3.2 | ||
Bone marrow femur: depletion/increased adipocytes | 1 day | incidence | 0 | 1 |
severity | — | 0.4 | ||
3 days | incidence | 0 | 2 | |
severity | — | 0.6 | ||
2 weeks | incidence | 0 | 5 | |
severity | — | 3.4 | ||
Bone marrow femur: atrophy | 1 day | incidence | 0 | 0 |
severity | — | — | ||
3 days | incidence | 0 | 0 | |
severity | — | — | ||
2 weeks | incidence | 0 | 5 | |
severity | — | 3.0 | ||
Spleen: reduced extramedullary hemopoiesis (erythropoiesis) | 1 day | incidence | 0 | 0 |
severity | — | — | ||
3 days | incidence | 0 | 5 | |
severity | — | 3.0 | ||
2 weeks | incidence | 3 | 5 | |
severity | 1.2 | 3.0 | ||
Bone, femur: atrophy/arrest growth plate | 1 day | incidence | 0 | 0 |
severity | — | — | ||
3 days | incidence | 0 | 4 | |
severity | — | 1.6 | ||
2 weeks | incidence | 0 | 5 | |
severity | — | 3.0 |
Incidence (number of animals; n = 5 per treatment group) of rotenone-caused histopathological changes in rats, after the three different treatment periods. The “severity” score indicates the mean severity from grading 1–5, representing minimal-slight-moderate-marked-massive, respectively.