. 2017 Apr 4;7:45465. doi: 10.1038/srep45465

Table 1. Major histopathological findings.

Organ: finding	Treatment duration	Score	Control	Rotenone
Liver: cytoplasmic change/atrophy	1 day	incidence	0	5
	1 day	severity	—	3.2
	3 days	incidence	0	5
	3 days	severity	—	2.8
	2 weeks	incidence	0	5
	2 weeks	severity	—	3.6
Bone marrow femur: hyperemia/sinus dilation	1 day	incidence	0	2
	1 day	severity	—	0.8
	3 days	incidence	0	5
	3 days	severity	—	2.0
	2 weeks	incidence	0	5
	2 weeks	severity	—	3.2
Bone marrow femur: depletion/increased adipocytes	1 day	incidence	0	1
	1 day	severity	—	0.4
	3 days	incidence	0	2
	3 days	severity	—	0.6
	2 weeks	incidence	0	5
	2 weeks	severity	—	3.4
Bone marrow femur: atrophy	1 day	incidence	0	0
	1 day	severity	—	—
	3 days	incidence	0	0
	3 days	severity	—	—
	2 weeks	incidence	0	5
	2 weeks	severity	—	3.0
Spleen: reduced extramedullary hemopoiesis (erythropoiesis)	1 day	incidence	0	0
	1 day	severity	—	—
	3 days	incidence	0	5
	3 days	severity	—	3.0
	2 weeks	incidence	3	5
	2 weeks	severity	1.2	3.0
Bone, femur: atrophy/arrest growth plate	1 day	incidence	0	0
	1 day	severity	—	—
	3 days	incidence	0	4
	3 days	severity	—	1.6
	2 weeks	incidence	0	5
	2 weeks	severity	—	3.0

Incidence (number of animals; n = 5 per treatment group) of rotenone-caused histopathological changes in rats, after the three different treatment periods. The “severity” score indicates the mean severity from grading 1–5, representing minimal-slight-moderate-marked-massive, respectively.