Table 4.
Sensitivity and specificity of 95th centile values of structural biomarker values from healthy volunteers in detecting functional-AKI
| Patients with albuminuria (n = 34) | No-albuminuria (n = 16) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Biomarkers (ng/mg Cr) |
Sensitivitya | Specificitya | Positive likelihood ratioa | Negative likelihood ratioa | Diagnostic odds ratioa | Sensitivitya | Specificitya | Positive likelihood ratioa | Negative likelihood ratioa | Diagnostic odds ratioa |
| uCysC | 96 (79–99) | 27 (10–56) | 1.3 (0.9–1.9) | 0.16 (0–1.4) | 8.2 (0.7–91.2) | 0 (0–56) | 100 (75–100) | 0 | 1 (1–1) | 0 |
| uClu | 91 (73–98) | 54 (28–79) | 2 (1–3.4) | 0.2 (0–0.7) | 12.6 (1.9–82) | 0 (0–56) | 100 (75–100) | 0 | 1 (1–1) | 0 |
| Uβ2M | 91 (73–98) | 27 (9–56) | 1.2 (0.8–1.8) | 0.3 (0–1.6) | 3.9 (0.5–28) | 100 (43–100) | 66 (39–86) | 3 (1.3–6.7) | 0 | 0 |
| uNGAL | 48 (29–57) | 91 (62–98) | 5.3 (0.8–35.8) | 0.6 (0.4–0.9) | 9.2 (1–83) | 33 (6–79) | 92 (64 (98) | 4 (0.3–47) | 0.7 (0.3–16) |
5.5 (0.2–129) |
| uKIM-1 | 60 (40–78) | 63 (35–85) | 1.7 (0.7–3.9) | 0.6 (0.3–1.2) | 2.7 (0.6–12) | 0 (0–56) | 1 (75–100) | 0 | 1 (1–1) | 0 |
a Data presented with 95% CI
Serum creatinine ≥ 100% (AKI ≥ 2) is defined as functional-AKI while biomarker concentration >95th centile value in healthy volunteers (uCysC: 70 ng/mg Cr; uClu: 420 ng/mg Cr; uKIM-1 1.2 ng/mg Cr; uβ2M 166 ng/mg Cr and uNGAL: 120 ng/mg Cr) were used to define structural-AKI