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Non-pharmacological and pharmacological strategies to reduce the WAT/BAT ratio in VAT and EAT depots
By changes in lifestyle and specific miRNA/gene expression, activation or transplantation of BAT, and bariatric surgery, the WAT/BAT ratio can be decreased. Metformin, PPARγ activators, anti-obesity drugs, statins, and more safely, incretins (stabilized by GLP-1R agonists and DPP-4 inhibitors), could also help to reduce this ratio
