Fig. 2.
KARE trial SPIRIT checklist. This checklist contains all trial-specific assessments that will be run on each study visit. An ‘X’ denotes that this assessment will be run. * Physical examination: cardiovascular, respiratory, gastrointestinal and neurological assessment to a level of detail that would be expected for a patient due to receive anesthesia. ** Vital Signs: Resting pulse, pulse oximetry and blood pressure for safety monitoring. Vital signs will also be continuously monitored throughout the infusion until the participant has recovered. Xa Bloods: Full Blood Count (haemoglobin, white cell count, platelets, mean red cell volume); Liver Function Tests (Bilirubin, Alanine aminotransferase, Asparate aminotransferase, Total Protein, Alkaline phosphatase, Albumin, Globulin, gamma-glutamyl transpeptidase), Biochemistry (urea, sodium, potassium, glucose, calcium, thyroid stimulating hormone). Xb Bloods: Liver Function Tests (same as above); Brain-derived neurotrophic factor; ketamine. Xc Urine drug screen panel (methamphetamine, cocaine, tetrahydrocannabinol, benzodiazepines, tricyclic antidepressants, barbiturates, phencyclidine, amphetamines, morphine, methadone) including ketamine. Xd Urine drug screen panel (same as above) excluding ketamine