Table 1.
TGFBR2-dependent exosomal proteome of HCT116 MSI tumor cells
| Uni_Prot | Gene | Protein description | Scores | Mass [Da] | Sign Prot matches | Sign Prot sequences | Coverage [%] |
|---|---|---|---|---|---|---|---|
| dTGFBR2 | |||||||
| CO3A1_HUMAN | COL3A1 | Collagen alpha-1(III) chain | 34 47 42 | 139733 | 1 0 1 | 1 0 1 | 0.8 1.4 0.8 |
| FAM3C_HUMAN | FAM3C | Protein FAM3C | 47 33 52 | 24950 | 1 1 1 | 1 1 1 | 5.7 5.7 5.7 |
| GMPR2_HUMAN | GMPR2 | GMP reductase 2 | 49 37 53 | 38363 | 0 1 0 | 0 1 0 | 8.3 3.4 8.3 |
| H2A2B_HUMAN | HIST2H2AB | Histone H2A type 2-B | 245 261 293 291 | 13987 | 8 7 8 9 | 4 4 4 4 | 52.3 52.3 52.3 52.3 |
| INVS_HUMAN | INVS | Inversin | 31 36 42 | 118837 | 0 2 2 | 0 1 1 | 0.6 0.6 0.6 |
| KPRA_HUMAN | PRPSAP1 | Phosphoribosyl pyrophosphate synthase-associated protein 1 | 39 60 64 | 39654 | 1 1 1 | 1 1 1 | 6.5 10.4 6.5 |
| LRC59_HUMAN | LRRC59 | Leucine-rich repeat-containing protein 59 | 32 52 79 | 35308 | 1 1 1 | 1 1 1 | 3.3 7.2 9.1 |
| LRRF1_HUMAN | LRRFIP1 | Leucine-rich repeat flightless-interacting protein 1 | 55 37 75 | 89826 | 1 1 1 | 1 1 1 | 1.5 1.5 3.1 |
| PCBP3_HUMAN | PCBP3 | Poly(rC)-binding protein 3 | 209 232 212 | 39725 | 5 7 7 | 3 4 4 | 13.7 17.5 15.4 |
| RFA2_HUMAN | RPA2 | Replication protein A 32 kDa subunit | 58 45 94 | 29342 | 1 1 2 | 1 1 2 | 4.4 4.4 12.6 |
| SYT5_HUMAN | SYT5 | Synaptotagmin-5 | 50 54 43 | 43216 | 1 1 1 | 1 1 1 | 1.6 1.6 1.6 |
| TOM70_HUMAN | TOMM70A | Mitochondrial import receptor subunit TOM70 | 48 83 53 | 68096 | 1 1 1 | 1 1 1 | 3 3 3 |
| U2AF1_HUMAN | U2AF1 | Splicing factor U2AF 35 kDa subunit | 40 35 51 | 28368 | 0 1 1 | 0 1 1 | 11.2 3.8 11.2 |
| ZO1_HUMAN | TJP1 | Tight junction protein ZO-1 | 40 61 83 | 195682 | 1 1 1 | 1 1 1 | 0.7 1.4 1.4 |
| pTGFBR2 | |||||||
| B3GN7_HUMAN | B3GNT7 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 | 30 44 57 | 46471 | 0 1 1 | 0 1 1 | 4.7 4.7 4.7 |
| DHE3_HUMAN | GLUD1 | Glutamate dehydrogenase 1, mitochondrial | 91 60 49 | 61701 | 2 1 0 | 2 1 0 | 5.9 3.4 3.9 |
| IL18_HUMAN | IL-18 | Interleukin-18 | 42 44 36 | 22597 | 1 1 1 | 1 1 1 | 13.5 13.5 13.5 |
| LOXL4_HUMAN | LOXL4 | Lysyl oxidase homolog 4 | 110 221 169 | 86425 | 2 3 3 | 2 3 3 | 4.8 9.1 10.3 |
| UBP6_HUMAN | USP6 | Ubiquitin carboxyl-terminal hydrolase 6 | 34 34 31 | 160781 | 1 2 1 | 1 1 1 | 0.4 0.4 0.4 |
Different numbers in each column (scores, sign. prot. matches, sign. prot. sequences, coverage) refer to values for three or four biological replicates