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. 2016 Dec 28;140(1):201–217. doi: 10.1093/brain/aww271

Figure 6.

Figure 6

p75NTR and TrKA receptors are upregulated on 5xFAD astrocytes similarly to human Alzheimer’s disease brains and their expression is modulated by hNGFp. hNGFp restores astrocyte morphology and amyloid-β species levels. (A) Confocal images and co-localization analysis showing the expression of p75NTR and TrkA on astrocytes cells (n = 5 with the exception for wild-type mice n = 8). (B) Confocal images and co-localization analysis showing the expression of p75NTR and TrkA on human Alzheimer’s disease (AD) astrocytes (n = 3). (C) Confocal images to detect GFAP and quantification of astrocytic volume (n = 20 cells per group). (D) Confocal images and co-localization showing GFAP, amyloid-β oligomers (AβO) and amyloid-β in astrocytes (n = 10 cells per group). Scale bars are representative of mean ± SD. Scale bars in A and D = 15 µm; B = 20 µm; C = 60 µm. CTRL = control; WT = wild-type. *P < 0.05; **P < 0.001; ***P < 0.0001.