Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr 3;214(4):1153–1167. doi: 10.1084/jem.20160880

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Lee et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 9. — Type I IFN activates NK cell IFN-γ production through the stimulation of IL-18 production in inflammatory monocytes during vaginal HSV-2 infection. Rapidly after HSV-2 infection, type I IFN is produced in the vaginal mucosa. Type I IFN induces CCL2 production from a cell type or types and recruits inflammatory monocytes to the site of infection. Type I IFN binds IFNAR on inflammatory monocytes and signals through IRF9 to induce their release of IL-18. IL-18 then ligates to IL-18R on NK cells to induce their production of IFN-γ.