Skip to main content
. 2017 Apr 3;214(4):1111–1128. doi: 10.1084/jem.20161382

Figure 4.

Figure 4.

Eros−/− mice are susceptible to L. monocytogenes infection and fail to form NETS but are resistant to melanoma metastasis. (A) Survival of control (three mice) and Eros−/− (five mice) mice after i.v. injection with L. monocytogenes. (B) Bacterial burden in liver and spleen of control and Eros−/− mice 3 d after infection with L. monocytogenes. Data in A and B are representative of three independent experiments. (C) Neutrophil extracellular trap formation in response to PMA by control and Eros−/− mice. NETosis is measured by absorbance of Sytox Green. (D) Representative staining of control and Eros−/− neutrophils with sytox green and anticitrullinated histone 3 antibody. (E) Number of lung metastases in control or Eros−/− mice 10 d after i.v. injection of B16-F10 melanoma cells. Error bars represent the SEM. **, P < 0.01; ***, P < 0.001. Data in A were analyzed by Log-rank test. Data in B and E were analyzed by Mann Whitney test. Data in C was analyzed by Tukey’s test. Data are representative of at least three independent experiments.