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. 2017 Apr 3;214(4):1029–1047. doi: 10.1084/jem.20161802

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© 2017 LeBlanc et al.

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Figure 5. — Scg3 is a DR-high angiogenic factor. (A–E) DR-high Scg3 selectively stimulated corneal angiogenesis in diabetic but not control mice. In contrast, DR-low HRP-3 induced angiogenesis in healthy but not diabetic mice. VEGF promoted angiogenesis in both healthy and diabetic mice. (A) Representative photographic images of corneal angiogenesis in diabetic and healthy mice. (B) DiI staining of corneal blood vessels. (A and B) Asterisks indicate the position of corneal implant. Bars, 500 µm. (C–E) Quantification of corneal angiogenesis in a blinded manner. (C) Total number of corneal vessels. (D) Number of branching points. (E) Total angiogenesis score. Sample sizes (number of cornea) are indicated at the bottom of the graphs. Data from different mice within the same groups are pooled and analyzed using one-way ANOVA. Data are ±SEM.