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. 2017 Apr 3;214(4):1029–1047. doi: 10.1084/jem.20161802

Table 1. DR-associated endothelial ligands identified by comparative ligandomics.

CCDS ID Protein Binding activity Activity Ratio
DR Control
DR-high ligands with increased binding to diabetic ECs
CCDS23347.1     Scg3a      1,731      0        1,732
CCDS18810     C1qba      837      0        838
CCDS15031     Fn1a      419      0        420
CCDS35631     Col4a3a      409      2        137
CCDS28285     APPa      206      1        104
CCDS22638     Cdh1a      132      0        133
DR-low ligands with decreased binding to diabetic ECs
CCDS40011     HRP-3a      48      11,140        0.0044
CCDS17457     HDGFa      0      83        0.0119
Internal positive and negative controls
VEGF-Phage      408      2,420        0.1689
GFP-Phage      10      10        1
Total identified sequences      489,126      473,965
Total identified ligands      1,548      844
Diabetes-related ligandsa      353↑      105↓
a

P < 0.001; DR versus control; χ2 test. Activity ratio = (DR + 1)/(Control + 1).