Table 2.
Mean craving scores by antipsychotic group
| Clozapine (n = 19) | Olanzapine (n = 9) | Risperidone (n = 9) | FGA (n = 10) | Two AP (n = 12) | Overall ANCOVA | ||
|---|---|---|---|---|---|---|---|
| TCQ Total | |||||||
| Baseline | 44.0 (16.2) | 49.4 (21.6) | 49.2 (16.7) | 41.1 (21.3) | 41.3 (21.3) | ||
| 15 minutes post cigarette | 48.9 (18.3) | 48.8 (21.7) | 48.1 (17.8) | 36.5 (20.1) | 45.7 (21.3) | ||
| F = 1.46, df = 4, p = 0.23 | |||||||
| TCQ Factor 1 (Emotionality) | |||||||
| Baseline | 9.1 (4.1) | 12.1 (5.4) | 11.2 (5.1) | 9.2 (5.6) | 8.8 (4.8) | ||
| 15 minutes post cigarette | 11.9 (5.2) | 11.1 (5.7) | 11.4 (5.0) | 8.3 (6.2) | 9.7 (4.7) | ||
| F = 1.53, df = 4, p = 0.21 | |||||||
| TCQ Factor 2 (Expectancy) | |||||||
| Baseline | 11.1 (4.8) | 12.8 (5.5) | 13.1 (5.5) | 11.1 (5.6) | 11.0 (6.1) | ||
| 15 minutes post cigarette | 13.6 (5.7) | 13.9 (5.6) | 11.3 (6.1) | 9.3 (5.9) | 12.5 (6.4) | ||
| F = 2.10, df = 4, p = 0.09 | |||||||
| TCQ Factor 3 (Compulsivity) | |||||||
| Baseline | 10.9 (5.4) | 11.4 (6.4) | 11.2 (4.2) | 9.7 (6.6) | 10.3 (5.8) | ||
| 15 minutes post cigarette | 10.7 (5.2) | 11.3 (6.5) | 11.6 (5.9) | 8.4 (4.9) | 10.6 (6.6) | ||
| F = 0.36, df = 4, p = 0.84 | |||||||
| TCQ Factor 4 (Pruposefulness) | |||||||
| Baseline | 12.9 (5.4) | 13.1 (5.4) | 13.7 (5.5) | 11.7 (5.9) | 11.3 (6.2) | ||
| 15 minutes post cigarette | 12.7 (5.0) | 12.4 (5.7) | 13.8 (5.7) | 10.5 (5.7) | 5.6 (3.0) | ||
| F = 0.95, df = 4, p = 0.44 | |||||||
Note. TCQ= Tobacco Craving Questionnaire- Short Form
Pairwise comparisons between the FGA group and clozapine found significantly lower craving for FGA relative to clozapine (difference ± SE = −10.5 ± 4.66, t = −2.25, p = 0.03, FDR-adjusted p value = 0.19). Exploratory pairwise comparisons with clozapine showed lower emotionality factor with FGA (8.3 ± 6.2) vs. clozapine (11.9 ± 5.2) (difference ± SE −3.70± 1.64, t = −2.25, p = 0.03, FDR-adjusted p-value = 0.19). The expectancy factor was lower in the FGA group (9.3 ± 5.9) vs. clozapine (13.6 ± 5.7) (difference ± SE −4.28 ± 1.75, t = −2.44, p = 0.018, FDR-adjusted p-value = 0.19). Additionally, the expectancy factor was lower in the risperidone group (11.3 ± 6.1) vs. clozapine (13.6 ± 5.7) (difference ± SE −3.71 ± 1.83, t = −2.03, p = 0.048, FDR-adjusted p-value = 0.24). After adjustment for performing 20 pairwise comparisons, none of these were statistically significant (for p < 0.05).