Direct to indirect assessments of treatment benefit. ADAS-COG, Alzheimer’s Disease Assessment Scale—Cognitive; ALS, amyotrophic lateral sclerosis; BPRS, Brief Psychiatric Rating Scale; COA, clinical outcome assessment; CT, computed tomography; ETDRS, Early Treatment Diabetic Retinopathy Study; EXACT-PRO, the EXAcerbaCTtions of chronic pulmonary disease tool; FVC, forced vital capacity; FEV1, forced expiratory volume in 1; FLU-PRO, InFLUenza Patient-Reported Outcome; HgbA1c, glycated hemoglobin; HIV, human immunodeficiency virus; MRI, magnetic resonance imaging; SDMT, Symbol Digit Modalities Test.