BIN2 regulates cellulose synthesis activity in Arabidopsis. (A) Without BRs (−BL), BIN2 is phosphorylated, and thus active. (B) Under these conditions, BIN2 phosphorylates CESA1, which, in turn, changes the speed, and thus the activity, of the CSC. (C) When BL is added (+BL), BIN2 becomes dephosphorylated by BSU1, which leads to CSC activation. (D and E) BIN2 activation may be inhibited by BK (GSK3 inhibitor), which leads to reduced BIN2 activity and activation of the CSC.