Fig. S3.

Plasma stauprimide levels upon oral administration in the initial PK study and the tolerability study. (A) Plasma stauprimide levels in the initial PK study. Stauprimide was administered as single dose at 20 mg/kg in 75% (vol/vol) PEG300; 25% (vol/vol) D5W. (B) Plasma stauprimide levels in the tolerability study. Samples were collected following the last dose in a 7-d, once-per-day dosing scheme. Stauprimide was orally administered at 50 mg/kg. Each line represents one animal in the dosing group.