Table S1.
MYC transcription suppression by stauprimide in various cancer cell lines
| Cancer type | Cell line | EC50, nm | Maximum Myc suppression, % |
| Breast cancer | MCF7 | 337 | 40 |
| MDA-MB-231 | 1,177 | 86 | |
| MDA-MB-468 | 1,326 | 36 | |
| Lung cancer | A549 | 29 | 40 |
| H441 | 1,112 | 17 | |
| H358 | 1,455 | 72 | |
| Melanoma | A375 | 716 | 78 |
| A2058 | 1,116 | 31 | |
| LOX-IMVI | 280 | 59 | |
| MDA-MB-435 | 39 | 35 | |
| MEWO | 119 | 33 | |
| MALME-3M | 2,691 | 38 | |
| Osteosarcoma | SK-ES-1 | 1,858 | 32 |
| SJSA-1 | 1,978 | 100 | |
| 143B | 177 | 100 | |
| G292 | 2,884 | 65 | |
| HOS | 563 | 95 | |
| U2OS | 916 | 69 | |
| SAOS | 3,038 | 63 | |
| Renal cancer | RXF393 | 609 | 100 |
| SN12C | 527 | 60 | |
| ACHN | 5,000 | 80 | |
| UO31 | 1,272 | 97 | |
| 786-0 | 3,252 | 70 | |
| A498 | 270 | 73 | |
| CAKI-1 | 962 | 100 | |
| TK10 | 426 | 100 | |
| Hematopoietic | KG1A | 399 | 89 |
| RAMOS | — | — | |
| CA46 | — | — | |
| MEG01 | 634 | 70 | |
| MOLT4 | 715 | 65 | |
| Prostate | PC3 | 1,055 | 41 |
| DU145 | 364 | 15 | |
| Colon cancer | Colo 205 | 8,000 | 70 |
| HT29 | 1,070 | 53 | |
| Ovary cancer | OVCAR3 | 130 | 17 |
| OVCAR4 | 274 | 47 | |
| OVCAR5 | 762 | 83 | |
| SKOV3 | 1,378 | 100 | |
| Murine cancer | B16 | 3,366 | 82 |
| MLE12 | 1,993 | 96 |
Cells were treated with stauprimide at various concentrations for 6 h and mRNA was extracted, relative MYC mRNA levels were quantified by qRT-PCR using either GAPDH or β-actin for normalization.