Table S3.

Stauprimide pharmacokinetic profile

Study	Initial PK	Tolerability
Dose, mg⋅kg	20	50
Administration	Single dose	Seven doses, SID
Cmax, ng⋅mL; nM	1,140 ± 72.1; 1,951 ± 123	1,275 ± 359; 2,182 ± 614
Tmax, h	1.7 ± 1.15	2 ± 0
T1/2, h	3.86 ± 0.28	16.78 ± 4.73
AUC0–24, h⋅ng⋅mL−1	12,050 ± 982	21,476 ± 4,087
Cl, mL⋅min⋅kg−1	27.2 ± 2.24	22.83 ± 4.09
Vd, L⋅kg	9.11 ± 1.21	33.41 ± 8.2
MRT, h		9.09 ± 1.33