Figure 1. Distribution of the natural product leads of approved and clinical trial drugs in branch 5 of the Scaffold-Hunter derived molecular scaffold trees of the 134,097 natural products and 411 natural product leads.

The drug-productive scaffolds or scaffold parent-child sub-branches (DSs) are indicated by red dots or red dots connected by red lines, which marked by the respective label DS15-DS19. The green triangles indicate the natural product leads outside the DSs. Some of the representative scaffolds in these DSs are shown in the Figure. The more complete sets of the representative scaffolds are shown in the Supplementary Figure S2.