Table 2. The statistical significance of the clustering of the NPLDs in every DC. MTd is the mean Tanimoto distance of the NPLDs in each DC, MTd.rnd is the mean Tanimoto distance in randomization, NRI is a standardized effect size measure of the community structure, and P-value is the number of randomly selected NPs that are more clustered than the NPLDs in each DC divided by the number of runs (60,000 in this study). P values in bold are the ones which remain significant after Bonferroni correction with conservative α′ = 0.05/60 = 0.000833.
| DC | Branch | No of NPLD | MTD | MTD.rnd | NRI | P-value |
|---|---|---|---|---|---|---|
| DC1 | 1 | 2 | 0.2642 | 1.8368 | 6.2835 | 0.00238 |
| DC2 | 1 | 2 | 0.1224 | 1.8373 | 6.9228 | 0.00117 |
| DC3 | 1 | 2 | 0.6296 | 1.8331 | 4.7303 | 0.00847 |
| DC4 | 3 | 4 | 1.0322 | 1.6705 | 6.1005 | 0.00047 |
| DC5 | 3 | 19 | 1.2111 | 1.6704 | 16.3408 | 0.00000 |
| DC6 | 3 | 5 | 1.2328 | 1.6704 | 5.2077 | 0.00142 |
| DC7 | 3 | 15 | 1.4909 | 1.6706 | 5.2466 | 0.00043 |
| DC8 | 3 | 6 | 1.0778 | 1.6706 | 8.2775 | 0.00003 |
| DC9 | 3 | 7 | 1.1073 | 1.6711 | 9.1502 | 0.00002 |
| DC10 | 3 | 5 | 0.8436 | 1.6704 | 9.8633 | 0.00000 |
| DC11 | 4 | 4 | 0.8826 | 1.5121 | 4.7221 | 0.00277 |
| DC12 | 4 | 5 | 0.6238 | 1.5122 | 8.4309 | 0.00000 |
| DC13 | 4 | 18 | 1.0751 | 1.5107 | 12.7659 | 0.00000 |
| DC14 | 7 | 5 | 0.8233 | 1.2803 | 4.4320 | 0.00177 |
| DC15 | 8 | 3 | 0.8090 | 1.5069 | 4.7523 | 0.00175 |
| DC16 | 9 | 3 | 0.4985 | 1.4882 | 5.2888 | 0.00145 |
| DC17 | 9 | 16 | 0.8576 | 1.4892 | 10.2529 | 0.00000 |
| DC18 | 9 | 2 | 1.0548 | 1.4913 | 1.5675 | 0.06920 |
| DC19 | 9 | 37 | 1.0487 | 1.4896 | 11.3267 | 0.00000 |
| DC20 | 10 | 2 | 0.1740 | 1.4029 | 5.8662 | 0.00135 |
| DC21 | 10 | 9 | 0.9145 | 1.4017 | 6.8067 | 0.00000 |
| DC22 | 10 | 3 | 0.7339 | 1.4007 | 4.5322 | 0.00078 |
| DC23 | 10 | 2 | 1.2542 | 1.3999 | 0.6864 | 0.15480 |
| DC24 | 11 | 5 | 0.8121 | 1.3910 | 5.5223 | 0.00100 |
| DC25 | 12 | 2 | 0.2934 | 1.2207 | 3.7910 | 0.00947 |
| DC26 | 12 | 2 | 0 | 1.2202 | 4.9798 | 0.00078 |
| DC27 | 12 | 8 | 0.9926 | 1.2208 | 2.9058 | 0.01428 |
| DC28 | 12 | 8 | 0.2007 | 1.2200 | 12.9182 | 0.00000 |
| DC29 | 12 | 7 | 0.7426 | 1.2203 | 5.5655 | 0.00043 |
| DC30 | 13 | 2 | 0.8474 | 1.3667 | 1.9145 | 0.06510 |
| DC31 | 14 | 5 | 1.0297 | 1.5449 | 4.2627 | 0.00100 |
| DC32 | 14 | 5 | 0.9406 | 1.5439 | 4.9565 | 0.00007 |
| DC33 | 14 | 4 | 1.1776 | 1.5454 | 2.5820 | 0.02413 |
| DC34 | 14 | 3 | 0.8209 | 1.5460 | 4.0057 | 0.00120 |
| DC35 | 14 | 6 | 0.6607 | 1.5452 | 8.3548 | 0.00000 |
| DC36 | 15 | 10 | 0.6860 | 1.3351 | 7.9798 | 0.00000 |
| DC37 | 16 | 3 | 0.6935 | 1.1435 | 3.4132 | 0.01103 |
| DC38 | 16 | 7 | 0.5400 | 1.1431 | 10.9642 | 0.00000 |
| DC39 | 17 | 3 | 0.4787 | 1.1665 | 5.0540 | 0.00093 |
| DC40 | 17 | 7 | 0.8464 | 1.1671 | 4.7313 | 0.00235 |
| DC41 | 17 | 2 | 0.6630 | 1.1649 | 2.3529 | 0.03623 |
| DC42 | 17 | 7 | 0.7352 | 1.1663 | 6.3612 | 0.00025 |
| DC43 | 20 | 5 | 0.4329 | 1.3241 | 17.2567 | 0.00000 |
| DC44 | 20 | 5 | 0.6912 | 1.3241 | 12.1159 | 0.00003 |
| DC45 | 20 | 7 | 0.9507 | 1.3238 | 10.0919 | 0.00002 |
| DC46 | 21 | 3 | 0.1372 | 0.7713 | 5.0125 | 0.00010 |
| DC47 | 21 | 4 | 0.5792 | 0.7708 | 1.8932 | 0.02985 |
| DC48 | 24 | 4 | 0.7416 | 1.0739 | 5.7931 | 0.00110 |
| DC49 | 24 | 6 | 0.5427 | 1.0740 | 14.5890 | 0.00000 |
| DC50 | 26 | 5 | 0.4218 | 0.7916 | 6.3884 | 0.00012 |
| DC51 | 26 | 2 | 0.6052 | 0.7909 | 1.1859 | 0.07355 |
| DC52 | 28 | 3 | 0.9049 | 1.1883 | 2.4123 | 0.03025 |
| DC53 | 28 | 9 | 0.9577 | 1.1880 | 5.9241 | 0.00070 |
| DC54 | 30 | 2 | 0.7262 | 0.8764 | 0.7311 | 0.18568 |
| DC55 | 32 | 3 | 0.3393 | 0.8538 | 4.4925 | 0.00152 |
| DC56 | 32 | 2 | 0.6884 | 0.8548 | 0.9532 | 0.12325 |
| DC57 | 32 | 2 | 0.2012 | 0.8550 | 3.7418 | 0.00427 |
| DC58 | 32 | 2 | 0.4916 | 0.8533 | 2.0560 | 0.05248 |
| DC59 | 32 | 3 | 0.2995 | 0.8535 | 4.8258 | 0.00077 |
| DC60 | 33 | 2 | 0 | 0.9059 | 5.0937 | 0.00040 |