Table 2.
Scores on Cognitive, Social Cognitive, and Reward Processing Outcome Measures, and Symptom Ratings and Functional Outcomes at Baseline, 40, and 70 Hours of Training in Participants who Received Targeted Cognitive Training plus Social Cognition Training (TCT+SCT) or Targeted Cognitive Training only (TCT-only).
| TCT+SCT | TCT-only | |||||||
|---|---|---|---|---|---|---|---|---|
| Outcome Measures | Baseline Mean (SE) N=57 |
40 Hours Mean (SE) N=38 |
70 Hours Mean (SE) N=29 |
Baseline Mean (SE) N=54 |
40 Hours Mean (SE) N=40 |
70 Hours Mean (SE) N=32 |
Main Effects of Time p Value |
Group x Time Interaction p Value |
| MATRICS Consensus Cognitive Batterya | ||||||||
| Global Cognition | 29.41 (1.89) | 31.69 (1.99) | 34.11 (2.22) | 31.84 (1.92) | 34.35 (1.99) | 35.09 (2.22) | <0.001 | 0.58 |
| Attention | 37.66 (1.73) | 37.46 (2.04) | 40.25 (2.08) | 39.36 (1.78) | 42.82 (2.04) | 43.16 (2.07) | 0.03 | 0.28 |
| Speed of Processing | 34.75 (1.77) | 35.60 (2.12) | 37.51 (2.32) | 36.62 (1.80) | 38.55) (2.13) | 41.46 (2.31) | 0.001 | 0.64 |
| Working Memory | 39.61 (1.70) | 39.41 (1.74) | 41.01 (1.94) | 39.97 (1.75) | 41.23 (1.75) | 42.14 (1.90) | 0.21 | 0.84 |
| Verbal Learning | 36.45 (1.16) | 38.04 (1.32) | 38.90 (1.83) | 37.91 (1.20) | 40.23 (1.32) | 39.99 (1.75) | 0.02 | 0.70 |
| Verbal Memoryb | 29.87 (2.04) | 28.82 (2.45) | 29.44 (2.76) | 32.52 (2.10) | 33.83 (2.45) | 32.28 (2.65) | 0.96 | 0.55 |
| Visual Learning | 35.63 (1.80) | 37.48 (1.99) | 42.22 (2.25) | 39.44 (1.85) | 43.02 (1.98) | 41.92 (2.20) | 0.01 | 0.07 |
| Visual Memoryb | 33.86 (2.22) | 37.52 (2.38) | 40.24 (2.91) | 38.13 (2.26) | 39.35 (2.35) | 38.87 (2.85) | 0.12 | 0.29 |
| Problem Solving | 39.61 (1.41) | 38.88 (1.54) | 43.08 (1.70) | 41.38 (1.45) | 43.50 (1.55) | 44.41 (1.69) | 0.002 | 0.11 |
| Social Cognition and Reward Processing Measures | ||||||||
| MSCEIT Perceiving Emotions | 42.30 (1.45) | 43.47 (1.79) | 45.58 (2.03) | 44.18 (1.49) | 44.75 (1.79) | 43.53 (2.01) | 0.50 | 0.32 |
| MSCEIT Managing Emotions | 40.40 (1.29) | 41.57 (1.29) | 41.30 (1.32) | 38.99 (1.33) | 39.22 (1.29) | 38.97 (1.32) | 0.70 | 0.60 |
| Prosody Identification Correct Responsesc | 31.48 (1.21) | 35.61 (1.74) | 37.98 (1.98) | 34.68 (1.91) | 35.21 (1.68) | 37.07 (1.94) | 0.001 | 0.05 |
| Prosody Identification Reaction Time (ms) | 4883.10 (194.47) | 4413.47 (192.86) | 3954.28 (139.52) | 4280.49 (190.41) | 4249.95 (183.16) | 4138.21 (135.92) | 0.001 | 0.03 |
| Faux Pas Test Percent Correct | 74.19 (1.96) | 77.61 (2.38) | 80.03 (2.72) | 76.56 (2.02) | 77.86 (2.34) | 78.94 (2.64) | 0.03 | 0.64 |
| TEPS Total Mean Item Score | 4.14 (0.11) | 4.37 (0.13) | 4.52 (0.13) | 4.41 (0.12) | 4.33 (0.13) | 4.23 (0.13) | 0.53 | 0.02 |
| TEPS Anticipatory Pleasure | 4.05 (0.12) | 4.27 (0.14) | 4.43 (0.15) | 4.34 (0.12) | 4.25 (0.14) | 4.12 (0.14) | 0.72 | 0.06 |
| TEPS Consummatory Pleasure | 4.23 (0.14) | 4.47 (0.14) | 4.63 (0.15) | 4.47 (0.14) | 4.40 (0.14) | 4.35 (0.15) | 0.32 | 0.04 |
| Symptom Ratings | ||||||||
| PANSS Total | 64.90 (2.09) | 63.00 (2.65) | 64.16 (2.71) | 62.17 (2.20) | 59.97 (2.69) | 57.72 (2.63) | 0.33 | 0.40 |
| PANSS Positive Symptoms | 15.68 (0.71) | 14.49 (0.74) | 14.97 (0.85) | 14.97 (0.74) | 15.62 (0.75) | 13.96 (0.85) | 0.17 | 0.09 |
| PANSS Negative Symptoms | 16.53 (0.72) | 15.83 (0.75) | 15.83 (0.84) | 14.81 (0.75) | 13.35 (0.77) | 14.02 (0.81) | 0.09 | 0.14 |
| PANSS General Psychopathology | 32.68 (1.12) | 31.95 (1.54) | 32.08 (1.54) | 32.39 (1.17) | 31.17 (1.56) | 30.33 (1.48) | 0.42 | 0.97 |
| Functional Outcomes | ||||||||
| UPSA-Briefd Total | 69.60 (1.92) | 70.35 (2.29) | 71.05 (2.50) | 70.91 (1.97) | 72.95 (2.28) | 77.48 (2.43) | 0.05 | 0.30 |
| Quality of Life Scale Mean Item Score | 3.10 (0.14) | 3.22 (0.15) | 3.24 (0.17) | 3.28 (0.15) | 3.40 (0.16) | 3.32 (0.17) | 0.35 | 0.77 |
| Social Functioning Scale—Average Subscale Score | 108.03 (1.14) | 108.20 (1.27) | 108.46 (1.14) | 107.92 (1.17) | 108.91 (1.27) | 107.28 (1.13) | 0.55 | 0.53 |
MATRICS Consensus Cognitive Battery (MCCB) Measures: Global Cognition (composite T-score across all MCCB measures); Attention (Continuous Performance Task-Identical Pairs); Speed of Processing (Trail Making Test Part A; Category Fluency Animal Naming; BACS Symbol Coding); Working Memory (Letter-Number Span; WMS-III Spatial Span); Verbal Learning (HVLT-R Immediate Recall); Visual Learning (BVMT-R Immediate Recall); Problem Solving (NAB Mazes); MSCEIT Managing Emotions (listed in Table 3).
In addition to the MCCB, verbal and visual Delayed Recall from the HVLT-R and BVMT-R were administered;
78 of the 111 participants completed the Prosody Identification Test.
University of California, San Diego, Performance-Based Skills Assessment—Brief.