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. 2017 Mar 30;22(1):40–46. doi: 10.15430/JCP.2017.22.1.40

Table 1.

Effect of the venoms at the IC50 value on the activity of the antioxidant enzymes and MDA level in PC3 cells

Variable/mg protein Control cell PC3 cells treated with

Androctonus amoreuxi Cerastes cerastes Mix of A. amoreuxi & C. cerastes venoms
CAT (mU) 0.84 ± 0.10 1.49 ± 0.12 (0.02) 2.90 ± 0.33 (0.04) 4.00 ± 0.27 (0.003)
SOD (U) 168.75 ± 0.81 232.20 ± 9.01 (0.03) 385.75 ± 32.78 (0.03) 638.24 ± 41.81 (0.01)
GPx (mU) 4.60 ± 0.31 7.64 ± 0.48 (0.02) 14.05 ± 0.49 (< 0.001) 13.03 ± 0.38 (0.0002)
GR (mU) 17.82 ± 0.43 27.73 ± 0.79 (0.003) 47.29 ± 4.01 (0.03) 86.27 ± 7.34 (0.02)
GST (mU) 3.09 ± 0.10 5.22 ± 0.26 (< 0.01) 8.97 ± 0.29 (0.004) 9.68 ± 0.24 (0.0002)
MDA level (nmol) 4.43 ± 0.20 6.77 ± 0.49 (0.04) 14.17 ± 0.90 (0.01) 16.17 ± 1.13 (0.01)

Values are present as mean ± SE (P value). PC3 cells were treated with the venoms for 24 hours. MDA, malondialdehyde; PC3, prostate cancer cell line; CAT, catalase; SOD, superoxide dismutase; GPx, glutathione peroxidase; GR, glutathione reductase, GST, glutathione-S-transferase.