Table 3.
Comparison of clinical characteristics between the slow-decrease (<200 mL/year) and rapid-decrease (≥200 mL/year) groups.
| At baseline | Slow-decrease group (n=9) | Rapid-decrease group (n=12) | P value |
|---|---|---|---|
| Age (years) | 57.6±12.2 | 55.7±13.4 | 0.80 |
| Sex (Male: Female) | 5: 4 | 8: 4 | 0.60 |
| Primary disease of ESRD (%) | 0.053 | ||
| Nephrosclerosis | 77.8 | 25.0 | |
| Chronic glomerulonephritis | 22.2 | 66.7 | |
| Diabetic nephropathy | 0 | 8.3 | |
| Cardiovascular disease (%) | 33.3 | 16.7 | 0.61 |
| ARB/ACE-i (%) | 88.9 | 58.3 | 0.18 |
| CCB (%) | 88.9 | 66.7 | 0.34 |
| Statin (%) | 33.3 | 8.3 | 0.27 |
| BMI (kg/m2) | 23.0±2.4 | 25.0±5.0 | 0.36 |
| SBP (mmHg) | 118.3±12.1 | 129.3±20.4 | 0.30 |
| DBP (mmHg) | 68.0±11.2 | 79.3±14.0 | 0.11 |
| Urine volume (mL/day) | 1535±392 | 1525±537 | 0.94 |
| Proteinuria (mg/day) | 344±208 | 979±458 | <0.001 |
| PD duration (months) | 17.9±9.2 | 13.0±12.8 | 0.24 |
| PD drainage volume (mL/day) | 315±243 | 256±336 | 0.55 |
| D/P Cr 4-hour | 0.62±0.08 | 0.64±0.09 | 0.52 |
| Total weekly Kt/V | 1.96±0.40 | 1.91±0.43 | 0.55 |
| Dialysate weekly Kt/V | 0.96±0.30 | 1.00±0.38 | 0.80 |
| Residual weekly Kt/V | 1.00±0.38 | 0.91±0.53 | 0.64 |
| Serum endocan (ng/mL) | 2.92±1.25 | 6.28±4.47 | 0.036 |
| Serum TNF-α (pg/mL) | 6.17±0.98 | 7.40±1.65 | 0.065 |
| Hb (g/dL) | 11.1±1.7 | 10.5±1.1 | 0.70 |
| Alb (g/dL) | 3.41±0.25 | 3.31±0.36 | 0.45 |
| CRP (mg/dL) | 0.09±0.11 | 0.46±0.83 | 0.39 |
| BUN (mg/dL) | 58.4±17.5 | 51.4±10.2 | 0.37 |
| Cr (mg/dL) | 7.74±2.55 | 9.74±3.60 | 0.27 |
| GFR (mL/min/1.73 m2) | 4.43±2.03 | 3.56±1.93 | 0.30 |
| β2-MG (mg/mL) | 14.5±2.9 | 16.4±5.2 | 0.59 |
| At the end of follow-up time | |||
| Follow-up duration (months) | 28.9±14.7 | 25.1±17.3 | 0.45 |
| Peritonitis rate (episodes/person-year) | 0.05 | 0.2 | 0.44 |
| Extent of changes in urine volume decrease (mL/year) | 18±134 | 505±265 | <0.001 |
Data are shown as n (%) or mean ± standard deviation. ESRD – end-stage renal disease; ARB – angiotensin II receptor blocker; ACE-i – angiotensin-converting enzyme inhibitor; CCB – calcium channel blocker; BMI – body mass index; SBP – systolic blood pressure; DBP – diastolic blood pressure; PD – peritoneal dialysis; D/P Cr – dialysate-to-plasma creatinine ratio; Kt/V – urea clearance index; TNF-α – tumor necrosis factor-α; Hb – hemoglobin; Alb – albumin; CRP – C-reactive protein; BUN – blood urea nitrogen; Cr – creatinine; GFR – glomerular filtration rate; β2-MG – β2-microglobulin.